Secarna Pharmaceuticals to present new data and clinical strategy for lead antisense oligonucleotide program SECN-15 at ASCO 2025
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EQS-News: Secarna Pharmaceuticals GmbH & Co. KG
/ Key word(s): Conference/Preliminary Results
Secarna Pharmaceuticals to present new data and clinical strategy for lead antisense oligonucleotide program SECN-15 at ASCO 2025
Martinsried (Munich), Germany, May 23, 2025 - Secarna Pharmaceuticals GmbH & Co. KG, a company redefining the discovery and development of best-in-class oligonucleotide therapeutics, will present new data on the company’s lead program, SECN-15, a potential first-in-class antisense oligonucleotide (ASO) targeting the transmembrane protein Neuropilin-1 (NRP1), at the American Society of Clinical Oncology (ASCO) Annual Meeting taking place May 30 – June 4 in Chicago, Illinois, USA. The new data being presented demonstrate that SECN-15 has a strong safety profile, with sustained systemic NRP1 downregulation, and is well tolerated in both mice and rats, supporting its potential for clinical development. In addition to these safety findings, SECN-15 demonstrates strong single agent and combination efficacy with immune checkpoint inhibitors (ICIs) in tumor models where ICIs have no or limited activity. This is underscored by the functional analysis of SECN-15’s mode of action, which shows that SECN-15 leads, among others, to reduction of genes associated with the epithelial-mesenchymal-transition (EMT), a pathway linked to ICI resistance in multiple solid tumor indications. These results position SECN-15 as a promising candidate for indications where current immunotherapies show limited benefit, such as gastric cancer, which will be a focus of the planned Phase I/II clinical trial to investigate SECN-15's safety and efficacy as monotherapy and in combination with PD-1 blocking antibodies. Poster presentation details: Title: SECN-15: A novel treatment option for patients with checkpoint inhibitor-resistant tumors by targeting Neuropilin-1 with antisense oligonucleotides "We’re pleased to present preclinical data with our lead program SECN-15 at this year’s ASCO Annual Meeting,” said Konstantin Petropoulos, PhD, Chief Executive Officer at Secarna Pharmaceuticals. “The preclinical results highlight SECN-15’s strong therapeutic potential, favorable safety and tolerability, and meaningful anti-tumor activity – alone or when combined with immune checkpoint inhibitors. These findings support our strategy of advancing SECN-15 into clinical development for cancers with high unmet medical need and limited response to current immunotherapies, such as gastric cancer. We are actively preparing for the first human trials to further explore this promising therapeutic strategy." About Secarna Pharmaceuticals Contact Secarna Pharmaceuticals GmbH & Co. KG Konstantin Petropoulos, PhD For media inquiries contact Lydia Robinson-Garcia
23.05.2025 CET/CEST Dissemination of a Corporate News, transmitted by EQS News - a service of EQS Group. |
2143752 23.05.2025 CET/CEST
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